Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling
Guofen Wang, Junsong Wang, Xian Li, Qiyang Wu, Ruifeng Yao, Xinjing Luo
Topics & Concepts
Tumor necrosis factor alphaHypoxia (environmental)Downregulation and upregulationNF-κBProinflammatory cytokineSignal transductionNFKB1Interleukin 6Internal medicineChemistryCancer researchCytokineEndocrinologyMedicineCell biologyBiologyTranscription factorInflammationBiochemistryGeneOxygenOrganic chemistryinterferon and immune responsesCancer-related molecular mechanisms researchCytokine Signaling Pathways and Interactions