Revisiting the Addition of in‐situ Nucleophiles to Allenic Ketones: An Entry Towards Synthesis of Benzodioxins
Sushree Ranjan Sahoo, Debayan Sarkar
Abstract
The manuscript delineates a revisit towards regioselective addition of in situ generated negative nucleophiles to allenic ketones in the presence of a base. A wide variety of allenic ketones as well as nucleophiles are viable in this transformation. A direct ring annulation towards the challenging benzodioxin skeleton synthesis has been developed. Environmentally benign protocol and wide substrate scope are the notable features of this methodology.
Topics & Concepts
NucleophileChemistryRegioselectivityAnnulationRing (chemistry)Scope (computer science)Substrate (aquarium)Combinatorial chemistryOrganic chemistryCatalysisOceanographyProgramming languageGeologyComputer scienceSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions