Evolutionary dynamics of neoantigens in growing tumors
Eszter Lakatos, Marc Williams, Ryan O. Schenck, William Cross, Jacob Househam, Luís Zapata, Benjamin Werner, Chandler Gatenbee, Mark Robertson‐Tessi, C. Barnes, Alexander R.A. Anderson, Andrea Sottoriva, Trevor A. Graham
Topics & Concepts
BiologyNegative selectionImmune systemNeutral theory of molecular evolutionSomatic evolution in cancerSomatic cellGermline mutationSelection (genetic algorithm)GeneticsMutationExomeClonal selectionPositive selectionCancerExome sequencingEvolutionary biologyGeneImmunologyGenomeComputer scienceArtificial intelligenceMonoclonal and Polyclonal Antibodies ResearchEvolution and Genetic DynamicsT-cell and B-cell Immunology