A heteromultivalent host–guest sensor array for cell recognition and discrimination
Xin‐Yue Hu, Zong‐Ying Hu, Jia‐Hong Tian, Lin Shi, Fei Ding, Hua‐Bin Li, Dong‐Sheng Guo
Abstract
We present a supramolecular sensor array based on a series of heteromultivalent macrocyclic coassemblies using amphiphilic calixarenes and cyclodextrin as the building blocks for cell recognition. The corresponding cross-reactivity between the coassemblies and cells served as the unique fingerprint for cell classification, and successfully identified the normal cell lines, cancerous cell lines, and cross-contaminated cells.
Topics & Concepts
Host (biology)Sensor arrayComputer scienceMolecular recognitionPattern recognition (psychology)ChemistryArtificial intelligenceBiologyMoleculeGeneticsOrganic chemistryMachine learningAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionSupramolecular Self-Assembly in Materials