SEOM clinical guideline on hereditary colorectal cancer (2019)
Carmen Guillén‐Ponce, Enrique Lastra, Isabel Lorenzo‐Lorenzo, Teresa Gómez, R. Morales Chamorro, Ana Beatriz Sánchez‐Heras, R. Serrano, Mari Carmen Rodríguez, José Luís Soto, Luis Robles
Abstract
In the last 2 decades, clinical genetics on hereditary colorectal syndromes has shifted from just a molecular characterization of the different syndromes to the estimation of the individual risk of cancer and appropriate risk reduction strategies. In the last years, new specific therapies for some subgroups of patients have emerged as very effective alternatives. At the same time, germline multigene panel testing by next-generation sequencing (NGS) technology has become the new gold standard for molecular genetics.
Topics & Concepts
MedicineGuidelineColorectal cancerCancerOncologyInternal medicineIntensive care medicineGynecologyPathologyGenetic factors in colorectal cancerColorectal Cancer Screening and DetectionColorectal Cancer Treatments and Studies