New Tripeptide Derivatives Asterripeptides A–C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2
Elena V. Girich, Anton B. Rasin, Roman S. Popov, Ekaterina A. Yurchenko, Ekaterina A. Chingizova, Phan Thi Hoai Trinh, Ngô Minh Ngọc, М. В. Пивкин, Olesya I. Zhuravleva, Anton N. Yurchenko
Abstract
Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey’s method. The isolated compounds 1–3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A–C were investigated.