MiR-144-3p inhibits the proliferation, migration and invasion of lung adenocargen cancer cells by targeting COL11A1
Yahong Sun, Zhihao Liu, Lifei Huang, Yan Shang
Abstract
This study aimed to investigate the regulatory relationship between miR-144-3p and COL11A1, and to explore its effect on the proliferation, migration and invasion of lung adenocarcinoma (LUAD) cells. A series of methods and experiments were applied. miR-144-3p was downregulated in LUAD tissue and cells, whereas COL11A1 was highly expressed. Overexpressing miR-144-3p inhibited the proliferation, migration and invasion of LUAD cells, which could be reversed by overexpression of COL11A1. Overexpressing miR-144-3p inhibits the proliferation, migration and invasion of LUAD cells by silencing COL11A1.
Topics & Concepts
Gene silencingAdenocarcinomaCancer researchCell migrationCell growthLung cancerLungBiologyCancerCell biologyCell cultureMedicinePathologyInternal medicineGeneGeneticsMicroRNA in disease regulationRNA modifications and cancerCircular RNAs in diseases