Pulsed Electromagnetic Fields Disrupt Staphylococcus epidermidis Biofilms and Enhance the Antibiofilm Efficacy of Antibiotics
Ryan B. Juncker, Beth Lazazzera, Fabrizio Billi
Abstract
Antibiotic resistance and biofilm infections are major issues in health care because of the lack of a successful treatment modality and poor patient outcomes. These infections are a particular issue following orthopedic surgery or trauma wherein an infection may form on an orthopedic implant or patient's bone. The presented study demonstrates that pulsed electromagnetic fields may be a promising novel treatment for such infections and can overcome the medical challenges presented by biofilm formation. Furthermore, the effects demonstrated are even greater when combining pulsed electromagnetic field therapy with traditional antibiotics.
Topics & Concepts
BiofilmStaphylococcus epidermidisAntibioticsOrthopedic surgeryMedicineIntensive care medicineAntibiotic resistanceStaphylococcus aureusOrthopedic traumaJoint infectionsMicrobiologySurgeryBiologyBacteriaArthroplastyGeneticsPeriprostheticMicrobial Inactivation MethodsBacillus and Francisella bacterial researchBacterial biofilms and quorum sensing