Rational design of novel microtubule targeting anticancer drugs N-imidazopyridine noscapinoids: Chemical synthesis and experimental evaluation based on in vitro using breast cancer cells and in vivo using xenograft mice model
Pratyush Pragyandipta, Ravi Kumar Pedapati, Praveen Kumar Reddy, Arnab Nayek, Rajesh Kumar Meher, Santosh Kumar Guru, Srinivas Kantevari, Pradeep Kumar Naik
Topics & Concepts
ImidazopyridineChemistryCytotoxicityApoptosisNoscapineCancer cellStereochemistryPharmacologyBiochemistryIn vitroCancer researchBiologyCancerAlkaloidGeneticsCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsPARP inhibition in cancer therapy