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An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and <i>in vivo</i>

Min Li, Jin Liu, Xuefei Chen, Yijing Dang, Yong Shao, Zhiai Xu, Wen Zhang

2022Chemical Communications15 citationsDOI

Abstract

We designed an activatable NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo .

Topics & Concepts

In vivoHDAC6Histone deacetylaseFluorescenceChemistryCancer researchPreclinical imagingHistone deacetylase inhibitorCancer cellCancerHistoneMolecular biologyBiophysicsMedicineBiochemistryBiologyDNAInternal medicinePhysicsQuantum mechanicsBiotechnologyHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisAdenosine and Purinergic Signaling
An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and <i>in vivo</i> | Litcius