Precise and fast control of the dissolved oxygen level for tumor-on-chip
Charlotte Bouquerel, William César, Lara Barthod, Sarah Arrak, Aude Battistella, Giacomo Gropplero, Fatima Mechta‐Grigoriou, Gérard Zalcman, Maria Carla Parrini, Marine Verhulsel, Stéphanie Descroix
Abstract
and pH pave the way for new precise investigations on physiological and pathological biological processes. Using Oxalis in the context of tumor-on-chip, we demonstrate the capacity of the system to recapitulate hypoxia-induced gene expression, offering an innovative strategy for future studies on the role of hypoxia in malignant progression and drug resistance.
Topics & Concepts
Volumetric flow rateOxygenChipLiquid flowChemistryShear stressAnalytical Chemistry (journal)Materials scienceChromatographyEngineeringComposite materialMechanicsElectrical engineeringOrganic chemistryPhysicsCancer, Hypoxia, and Metabolism3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques Innovation