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Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Shulei Pan, Yangli Zhou, Qiusheng Wang, Yanlin Wang, Chenyu Tian, Tianqi Wang, Luyi Huang, Jinshan Nan, Linli Li, Shengyong Yang

2020European Journal of Medicinal Chemistry34 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIndoleamine 2,3-dioxygenaseStereochemistryIn vivoKynurenineStructure–activity relationshipDioxygenaseIC50Kynurenine pathwayTriazoleArylCancer immunotherapy1,2,3-TriazoleTryptophanImmunotherapyEnzymeIn vitroBiochemistryImmune systemImmunologyAmino acidBiologyAlkylBiotechnologyOrganic chemistryTryptophan and brain disordersBipolar Disorder and TreatmentImmune cells in cancer
Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO) | Litcius