CSRP2 suppresses colorectal cancer progression <i>via</i> p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways
Lixia Chen, Xiaoli Long, Shiyu Duan, Xunhua Liu, Jian‐Xiong Chen, Jiawen Lan, Xuming Liu, Wen-Qing Huang, Jian Geng, Jun Zhou
Abstract
Our results suggest that the CSRP2/p130Cas/Rac1 axis can inhibit CRC aggressiveness and metastasis through the Hippo, ERK, and PAK signaling pathways. Therefore, CSRP2 may be a potential therapeutic target for CRC.
Topics & Concepts
Hippo signaling pathwayRAC1Colorectal cancerMAPK/ERK pathwayCancer researchSignal transductionMedicineChemistryCell biologyCancerInternal medicineBiologyCancer Mechanisms and TherapyCancer Cells and MetastasisFOXO transcription factor regulation