Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli
Gaofei Du, Yu Dong, Xiaolu Fan, Ankang Yin, Yao-Jin Le, Xiao-Yan Yang
Abstract
iron ion homeostasis remains unknown. To comprehensively reveal the antibacterial mechanisms of CFDC, data-independent acquisition quantitative proteomics combined with cellular and molecular biological assays were performed in this study. The findings will further facilitate our understanding of the antibacterial mechanism of CFDC and may provide a theoretical foundation for controlling CFDC resistance in the future.
Topics & Concepts
Escherichia coliSiderophoreBiochemistryChemistryReactive oxygen speciesOxidative stressBiologyMicrobiologyGeneAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntibiotics Pharmacokinetics and Efficacy