A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum
Emma M. Coomans, Inge M.W. Verberk, Rik Ossenkoppele, Sander C.J. Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E. Wolters, Tessa Timmers, Albert D. Windhorst, Sandeep S.V. Golla, Philip Scheltens, Wiesje M. van, der Flier, Bart N.M. van Berckel, Charlotte E. Teunissen
Abstract
Both plasma tau phosphorylated at threonine-181 (pTau181) and tau positron emission tomography (tau-PET) show potential for detecting Alzheimer's disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau-PET along the AD continuum.
Topics & Concepts
DementiaInternal medicineNeuropsychologyNuclear medicinePsychologyPositron emission tomographyMedicineAlzheimer's diseaseCohortCognitive declineOncologyCognitionPathologyDiseaseNeuroscienceDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsS100 Proteins and Annexins