On the prospect of achieving accurate joint estimation of selection with population history
Parul Johri, Adam Eyre‐Walker, Ryan N. Gutenkunst, Kirk E. Lohmueller, Jeffrey D. Jensen
Abstract
As both natural selection and population history can affect genome-wide patterns of variation, disentangling the contributions of each has remained as a major challenge in population genetics. We here discuss historical and recent progress towards this goal-highlighting theoretical and computational challenges that remain to be addressed, as well as inherent difficulties in dealing with model complexity and model violations-and offer thoughts on potentially fruitful next steps.
Topics & Concepts
BiologySelection (genetic algorithm)Joint (building)PopulationEstimationEvolutionary biologyComputer scienceDemographyMachine learningEngineeringSystems engineeringArchitectural engineeringSociologyEvolution and Genetic DynamicsGenetic diversity and population structureWheat and Barley Genetics and Pathology