Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction
Dhulfiqar Ali Abed, Sumi Lee, Longqin Hu
Topics & Concepts
ChemistryPotencyKEAP1XylyleneOxidative stressDrug discoveryDocking (animal)BiochemistryLead compoundReactive oxygen speciesPharmacologyDrugSmall moleculeIn vitroCombinatorial chemistryTranscription factorOrganic chemistryGeneNursingMedicineGenomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsRedox biology and oxidative stress