Catalytic Hydrodifluoroalkylation of Unactivated Olefins
Wen‐Jun Yue, Craig S. Day, Adrian J. Brenes Rucinski, Rubén Martı́n
Abstract
precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks. Our approach is enabled by a cooperative interplay of halogen- and hydrogen-atom transfer, thus offering a new entry point to difluorinated alkyl bioisosteres of interest in drug discovery.
Topics & Concepts
ChemistryCatalysisOlefin fiberHalogenCombinatorial chemistryStereocenterSelectivityModular designAlkylOrganic chemistryEnantioselective synthesisComputer scienceOperating systemFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCarbon dioxide utilization in catalysis