Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery (Adv. Funct. Mater. 21/2022)
Long Lin, Yuqiong Wang, Minkun Cai, Xinran Jiang, Yongyan Hu, Zaizai Dong, Dedong Yin, Yilin Liu, Shaohua Yang, Zhiguang Liu, Jian Zhuang, Ye Xu, Chuan Fei Guo, Lingqian Chang
Abstract
Microneedle–Microelectroporation Platform In article number 2109187, Jian Zhuang, Chuan Fei Guo, Lingqian Chang, and co-workers report a multimicrochannel microneedle microporation platform for drug delivery in vivo. The 4M platform offers a concentrated, safe electric field that not only accelerates the movement of cargo into deep tissue under electrophoresis, but also triggers cell electroporation, achieving enhanced transport across the cell membrane.
Topics & Concepts
ElectroporationDrug deliveryMaterials scienceNanotechnologyIn vivoIntracellularBiomedical engineeringBiophysicsMedicineCell biologyChemistryBiologyBiotechnologyGeneBiochemistryMicrobial Inactivation Methods