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The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold

Xinyu Liu, Riley Waters, Hannah E. Gilbert, Gage T. Barroso, Kelsey M. Boyle, Leah S. Witus

2021RSC Advances12 citationsDOIOpen Access PDF

Abstract

Peptide catalysts based on <bold>TrpZip</bold> scaffolds for the hydrolysis of <italic>para</italic>-nitrophenylacetate in aqueous media were found to have higher catalytic activity in sequences without <italic>β</italic>-hairpin character.

Topics & Concepts

ScaffoldHydrolysisPeptideCatalysisChemistryCombinatorial chemistryBiochemistryBiomedical engineeringEngineeringChemical Synthesis and AnalysisClick Chemistry and ApplicationsSupramolecular Self-Assembly in Materials
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