Context-dependent transcriptional regulations of YAP/TAZ in cancer
Yibo Guo, Juan Luo, Hailin Zou, Chenxin Liu, Liang Deng, Peng Li
Abstract
As the downstream effectors of Hippo pathway, YAP/TAZ are identified to participate in organ growth, regeneration and tumorigenesis. However, owing to lack of a DNA-binding domain, YAP/TAZ usually act as coactivators and cooperate with other transcription factors or partners to mediate their transcriptional outputs. In this article, we first present an overview of the core components and the upstream regulators of Hippo-YAP/TAZ signaling in mammals, and then systematically summarize the identified transcription factors or partners that are responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
Topics & Concepts
Hippo signaling pathwayEffectorTranscription factorBiologyCarcinogenesisCell biologyTranscription (linguistics)Transcriptional regulationContext (archaeology)Cancer researchGeneticsCancerGenePhilosophyLinguisticsPaleontologyHippo pathway signaling and YAP/TAZ