Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1<i>H</i>)-ones with CDCl<sub>3</sub> as the “CD<sub>3</sub>” source
Mei‐Chun Wu, Mingzhi Li, Yixuan Chen, Fang Liu, Jun‐An Xiao, Kai Chen, Hao‐Yue Xiang, Hua Yang
Abstract
Herein, readily available and inexpensive CDCl3 was first identified as a new trideuteromethylation reagent under photoredox-catalyzed conditions. Thus, a facile photocatalytic protocol for the C–H trideuteromethylation of quinoxalin-2(1H)-one was achieved. This operationally straightforward transformation displays a broad scope and provides a new route to introduce the trideuteromethyl group (CD3) with excellent levels of deuterium content.
Topics & Concepts
ChemistryReagentCatalysisCombinatorial chemistryPhotoredox catalysisDeuteriumScope (computer science)Transformation (genetics)PhotocatalysisOrganic chemistryComputer scienceBiochemistryProgramming languageGenePhysicsQuantum mechanicsChemical Reactions and IsotopesFluorine in Organic ChemistryEpigenetics and DNA Methylation