SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity
Sofía C. Khouili, Emma C. L. Cook, Elena Hernández‐García, María Martínez‐López, Ruth Conde‐Garrosa, Salvador Iborra
Abstract
cell-based vaccination against the parasite. Thus, SHP-1-mediated impairment of cross-presentation can be exploited by pathogens to evade CTLs, and SHP-1 inhibition improves CTL responses during vaccination.
Topics & Concepts
Cross-presentationLeishmaniaImmunityAntigen presentationAntigenBiologyImmunologyLeishmania majorCell biologyVirologyComputational biologyImmune systemComputer scienceT cellParasite hostingWorld Wide WebResearch on Leishmaniasis StudiesImmune Cell Function and InteractionT-cell and B-cell Immunology