Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
Julia Ramírez, Stefan van Duijvenboden, William J. Young, Michele Orini, Pier D. Lambiase, Patricia B. Munroe, Andrew Tinker
Abstract
). Sex-specific analyses indicated seven additional loci. In total, we identify 32 loci for resting Tpe, 3 for Tpe response to exercise and 3 for Tpe response to recovery modulating ventricular repolarization, as well as cardiac conduction and contraction. Our findings shed light on the genetic basis of resting Tpe and Tpe response to exercise and recovery, unveiling plausible candidate genes and biological mechanisms underlying ventricular excitability.
Topics & Concepts
Interval (graph theory)CardiologyInternal medicineGeneticsBiologyMedicineMathematicsCombinatoricsCardiac electrophysiology and arrhythmiasCardiovascular Effects of ExerciseCardiovascular Function and Risk Factors