Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Rachel L. Kember, Rachel Vickers‐Smith, Heng Xu, Sylvanus Toikumo, Maria Niarchou, Hang Zhou, Emily E. Hartwell, Richard C. Crist, Christopher T. Rentsch, Million Veteran Program, Lea K. Davis, Amy C. Justice, Sandra Sanchez‐Roige, Kyle M. Kampman, Joel Gelernter, Henry R. Kranzler
Topics & Concepts
Opioid use disorderAddictionGenome-wide association studyGeneticsHeritabilityLocus (genetics)BiologySubstance abuseDiseaseMeta-analysisPsychiatryOpioidGenePsychologyMedicineNeuroscienceSingle-nucleotide polymorphismGenotypeInternal medicineReceptorAlcohol Consumption and Health EffectsGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior