Bioinspired NO release coating enhances endothelial cells and inhibits smooth muscle cells
Shengyu Chen, Jing Wang, Fan Jia, Zhida Shen, Wenbin Zhang, Youxiang Wang, Ke‐feng Ren, Guosheng Fu, Jian Ji
Abstract
, into rapamycin coating to alleviate endothelial damage while inhibiting SMC proliferation. Through wicking effects, SNAP was absorbed into a hierarchical coating that had an upper porous layer and a dense polymer layer with rapamycin at the bottom. Cells were cultured on the coatings, and it was observed that the injured ECs were restored while the growth of SMCs further diminished. Genome analysis was conducted to further clarify possible signaling pathways: the effect of cell growth attenuated by NO may cause by affecting cell cycle and enhancing inflammation. These findings supported the idea that introducing NO to traditional drug-eluting stents alleviates incomplete endothelialization and further inhibits the stenosis caused by the proliferation of SMCs.