Novel Pyridazin-3(2<i>H</i>)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity
María Carmen Costas-Lago, Noemí Vila, Adeyemi Rahman, Pedro Besada, Isabel Rozas, José Brea, Marı́a Isabel Loza, Elisa González‐Romero, Carmen Terán
Abstract
with a bis-guanidinium structure display a weak DNA binding affinity and exhibit a reasonable cellular viability inhibition percentage in the three cancer cell lines studied.
Topics & Concepts
GuanidineMoietyChemistryDNAMinor grooveHydrochlorideCombinatorial chemistryStereochemistryHydrolysisDocking (animal)BiochemistryMedicineNursingSynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applicationsSynthesis and biological activity