Impact of the cAMP-cAMP Receptor Protein Regulatory Complex on Lipopolysaccharide Modifications and Polymyxin B Resistance in Escherichia coli
Alexandria B. Purcell, Brent W. Simpson, M. Stephen Trent
Abstract
Gram-negative bacteria can alter the structure of their LPS to promote resistance to cationic antimicrobial peptides, including polymyxin antibiotics. Polymyxins are considered last-resort antibiotics for treatment against multidrug-resistant Gram-negative organisms. Here, we explore how changes in general metabolism and carbon catabolite repression pathways can alter LPS structure and influence polymyxin resistance.
Topics & Concepts
PolymyxinPolymyxin BBiologyCatabolite repressionMicrobiologyEscherichia coliAntibioticsGram-negative bacteriaBacterial outer membraneLipopolysaccharidecAMP receptor proteinBacteriaAntibiotic resistanceBiochemistryImmunologyGeneGene expressionPromoterGeneticsMutantAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentTuberculosis Research and Epidemiology