Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells
Rohit B. Sharma, Christine Darko, Laura Alonso
Abstract
splicing did not decrease induction of ATF6α targets. Taken together, these data suggest that the XBP1 and ATF6 pathways are simultaneously activated in islet cells in response to acute stress and that ATF6α is required for full activation of XBP1 targets, but XBP1 is not required for activation of ATF6α targets. These observations improve understanding of the ER stress transcriptional response in pancreatic islets.
Topics & Concepts
XBP1Unfolded protein responseIsletIntersection (aeronautics)ATF6Cell biologyBiologyEndoplasmic reticulumEndocrinologyDiabetes mellitusGeneticsGeneGeographyCartographyRNA splicingRNAEndoplasmic Reticulum Stress and DiseasePancreatic function and diabetesImmune Cell Function and Interaction