Fluorinated phosphoric acid as a versatile effective catalyst for synthesis of series of benzimidazoles, benzoxazoles and benzothiazoles at room temperature
Sushil R. Mathapati, Komal Patil, Sujit S. Mathakari, A. W. Suryawanshi, Arvind H. Jadhav
Abstract
The present work describes synthesis of a series of benzimidazoles, benzoxazoles and benzothiazoles through the cyclization of 1, 2-phenylenediamine, 2-aminothiophenol, or 2-aminophenol with aryl, aliphatic and heteroaryl aldehydes. The present synthetic protocol is very much efficient in presence of 5 mol % fluorophosphoric acid as a catalyst in ethanol solvent at room temperature. Shorter reaction time, simple work-up technique, high yields and easy availability are specific compensations of the present synthetic approach.
Topics & Concepts
Phosphoric acidCatalysisSolventChemistryArylCombinatorial chemistryEthanolOrganic chemistryAlkylSynthesis and biological activityMulticomponent Synthesis of HeterocyclesChemical Synthesis and Reactions