Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs
Nilüfer Bayrak, Halil I. Ciftci, Mahmut Yıldız, Hatice Yıldırım, Belgin Sever, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Amaç Fatih Tuyun
Topics & Concepts
HeLaJurkat cellsChemistryApoptosisK562 cellsCancer cellDNA fragmentationCell cultureCytotoxic T cellBiochemistryGrowth inhibitionMolecular biologyIn vitroStereochemistryProgrammed cell deathBiologyCancerImmunologyT cellGeneticsImmune systemBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsSynthesis and biological activity