1β–OH–arenobufagin induces mitochondrial apoptosis in hepatocellular carcinoma through the suppression of mTOR signaling pathway
Lijuan Deng, Yuhe Lei, Jingyu Quan, Bao-Jing Li, Dongmei Zhang, Hai‐Yan Tian, Ye Chen, Enxin Zhang, Lei Chen, Wen‐Cai Ye, Weimin Ning, Linzhong Yu, Junshan Liu
Topics & Concepts
ApoptosisPI3K/AKT/mTOR pathwayIn vivoAnnexinMolecular biologyMTT assayCytotoxicityBlotChemistryTransfectionHepatocyteDownregulation and upregulationCancer researchSignal transductionMitochondrionIn vitroBiologyBiochemistryGeneBiotechnologyIon Transport and Channel RegulationPhytochemical Studies and BioactivitiesNatural product bioactivities and synthesis