A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy
Zhijian Chang, Jia‐Hai Ye, Fen Qi, Hongbao Fang, Fuyan Lin, Shuai Wang, Cancan Mu, Wenchao Zhang, Weijiang He
Abstract
A novel chemo-photodynamic combined therapeutic self-assembly polymeric platform (MPEG-Hyd-Br<sub>2</sub>-BODIPY) was constructed which can encapsulate DOX and exhibited an accelerated release rate with decreasing pH value which results in considerable time/dose-dependent cytotoxicity.
Topics & Concepts
ChemistryNanocarriersPhotodynamic therapyPhotosensitizerCytotoxicityBODIPYChemotherapyNanotechnologyCombinatorial chemistryDrug deliveryFluorescencePhotochemistryOrganic chemistryBiochemistryIn vitroSurgeryMedicineQuantum mechanicsMaterials sciencePhysicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials