Novel histone deacetylase 6 inhibitors using benzimidazole as caps for cancer treatment
Phuong Hong Nguyen, Bùi Thị Bửu Huê, Phạm Minh Quân, Tran Phuong Hoa, Quang De Tran, Hosun Jung, Le Trong Hieu, Cường Quốc Nguyễn, Hong Vinh Quang, Nguyen Phu Quy, Hye Jin Yoo, Su‐Geun Yang
Abstract
A cap of benzimidazole and a four carbon-chain-containing thioether linker is a superior HDAC6 inhibitor to belinostat.
Topics & Concepts
ChemistryBenzimidazoleThioetherLinkerHDAC6Histone deacetylase inhibitorHistone deacetylaseHDAC1PharmacologyBiochemistryCancer researchStereochemistryHistoneOrganic chemistryGeneOperating systemMedicineBiologyComputer scienceHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisProtein Degradation and Inhibitors