Histological Evaluation of Human Pulp Response to Direct Pulp Capping with MTA, CEM Cement, and Biodentine.
Razieh Hoseinifar, Ali Eskandarizadeh, Masoud Parirokh, Molook Torabi, Fereshteh Safarian, Elina Rahmanian
Abstract
STATEMENT OF THE PROBLEM: Direct pulp capping (DPC) is an established method in which the exposed pulp is coated with a suitable material to prevent further damage and to help its repair and healing. Different proposed materials may have different impact on pulp response during this treatment. PURPOSE: The purpose of this study was to compare the response of human dental pulp after DPC with calcium-enriched mixture (CEM), mineral trioxide aggregate (MTA) cement, and Biodentine. MATERIALS AND METHOD: In this clinical trial study, class V cavities were prepared on the buccal surfaces of 30 human premolar teeth, until the pulps were mechanically exposed. Then, teeth were randomly pulp capped with MTA, CEM cement and Biodentine, followed by resin modified glass ionomer filling. The fourth group was the control group (n= 10), in which the teeth were extracted without any prior intervention. Six weeks after the intervention, the teeth were extracted and prepared for histological evaluation in terms of the type and degree of pulp inflammation, dentin bridge formation and the presence of necrosis. Data were analyzed using Kruskal-Wallis and Mann Whitney U tests. RESULTS: = 0.011, respectively). CONCLUSION: Although the dentin bridge formation and the thickness of dentin bridge formed in the Biodentine group were higher than the other groups, pulp showed greater inflammation compared to CEM cement and MTA. The results of this study suggested that MTA and CEM cement performed better when employed as the direct pulp capping material.