Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis
Adam Greenfield, Erin Deja, Kimberly Lee, Sangeeta Sastry, Barry Rittmann
Abstract
Oxazolidinone antibiotics-linezolid and tedizolid-are often used to treat multidrug-resistant infections. They are highly bioavailable and ideal for transition to enteral therapy when appropriate. However, multiple associated adverse effects are potentially treatment-limiting. The objective of this review is to discuss relevant adverse effects of linezolid and tedizolid, including serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis, and their commonality in real-world experience in the last decade. Mitigation strategies, including the role of therapeutic drug monitoring, are also discussed.
Topics & Concepts
Serotonin syndromeLactic acidosisLinezolidMedicineAdverse effectInternal medicineSerotoninAcidosisBiologyVancomycinBacteriaReceptorStaphylococcus aureusSerotonergicGeneticsElectroconvulsive Therapy StudiesTreatment of Major DepressionTakotsubo Cardiomyopathy and Associated Phenomena