Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury
Wojciech Czyżewski, Jakub Litak, Jan Sobstyl, Tomasz Mandat, Kamil Torres, Grzegorz Staśkiewicz
Abstract
Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.
Topics & Concepts
Traumatic brain injuryAquaporinBrain edemaNeuroscienceMedicineBrain functionFunction (biology)BioinformaticsBiologyCell biologyPathologyPsychiatryIon Transport and Channel RegulationCerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances