A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues
Matthew H.W. Chin, Michael D. A. Norman, Eileen Gentleman, Marc‐Olivier Coppens, Richard M. Day
Abstract
< 0.001) to enhance IL-2 secretion. Our results demonstrate the importance of physical parameters in immune cell stimulation and highlight the potential of designing future immunostimulatory biomaterials that are mechanically tailored to balance stimulatory strength and downstream proliferative capacity of therapeutic T cells.
Topics & Concepts
Jurkat cellsSelf-healing hydrogelsCD28Materials scienceT cellBiophysicsCell cultureCellCell biologyImmune systemChemistryBiologyImmunologyBiochemistryPolymer chemistryGeneticsCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsImmunotherapy and Immune Responses