Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquín Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekström, Gerald M. McInerney, B.M. Hallberg, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Abstract
20 allele but lost when reverting to other IGHV1-69 alleles. Structural data confirmed that two germline-encoded polymorphisms, R50 and F55, in the IGHV1-69 gene were required for high-affinity receptor-binding domain interaction. These results demonstrate that polymorphisms in IGH genes can influence the function of SARS-CoV-2 neutralizing antibodies.
Topics & Concepts
BiologyGermlineAlleleIGHV@GeneticsAntibodySomatic hypermutationGeneLocus (genetics)Immunoglobulin heavy chainB cellLeukemiaChronic lymphocytic leukemiaSARS-CoV-2 and COVID-19 ResearchPhagocytosis and Immune RegulationViral gastroenteritis research and epidemiology