Interactions of polymyxin B with lipopolysaccharide-containing membranes
Alice Goode, Vivien Yeh, Boyan B. Bonev
Abstract
P MAS NMR relaxation is used to monitor selective molecular interactions between polymyxin B and rLPS within bilayer lipid membranes. We observe a strong facilitating effect from rLPS on the membrane lytic properties of polymyxin B and a specific, pyrophosphate-mediated process of molecular recognition of LPS by polymyxin B.
Topics & Concepts
Polymyxin BPolymyxinLipopolysaccharideBacterial outer membraneMembraneChemistryMicrobiologyAntibioticsBiochemistryBiologyEscherichia coliImmunologyGeneAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentTuberculosis Research and Epidemiology