A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre, Roberto Zoncu, Diego L. Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gérard Karsenty, Michel Vellard, Valeria Facchinetti, David M. Sabatini, Andrea Ballabio
Topics & Concepts
TFEBLysosomemTORC1Cell biologyBiologyAutophagyMechanistic target of rapamycinPI3K/AKT/mTOR pathwayBasic helix-loop-helix leucine zipper transcription factorsTranscription factorSignal transductionBiochemistryGeneDNA-binding proteinEnzymeApoptosisCalcium signaling and nucleotide metabolismAutophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer