Efficient hydroxyl radical generation of an activatable phthalocyanine photosensitizer: oligomer higher than monomer and nanoaggregate
Li Li, Yalan Liao, Shuwen Fu, Zixuan Chen, Tinghe Zhao, Luyue Fang, Xingshu Li
Abstract
assays illustrated that the oligomeric phthalocyanine containing N-O units (OligPcNOB) can specifically target cancer cells and tumor tissue with overexpressing biotin receptors. OligPcNOB exhibited significant photocytotoxicity even in an extremely low oxygen environment and successfully inhibited tumor progression.
Topics & Concepts
PhotosensitizerOligomerMonomerChemistrySupramolecular chemistryPhotochemistryPhotodynamic therapyPhthalocyanineMoleculeOrganic chemistryPolymerPorphyrin and Phthalocyanine ChemistryNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials