Green Synthesis, Antioxidant, and Plant Growth Regulatory Activities of Novel α-Furfuryl-2-alkylaminophosphonates
Maheshwara Reddy Nadiveedhi, Poojith Nuthalapati, Mohan Gundluru, Mohan Reddy Yanamula, Saritha Venkatareddy Kallimakula, Visweswara Rao Pasupuleti, Vijaya Kumar Reddy Avula, Swetha Vallela, Grigory V. Zyryanov, Satheesh Krishna Balam, C. Suresh Reddy
Abstract
studies have been further supported by ADMET (absorption, distribution, metabolism, excretion, and toxicity), quantitative structure-activity relationship, molecular docking, and bioactivity studies and identified that they were potentially bound to the GLN340 amino acid residue in chain C of 1DNU protein and TYR597 amino acid residue in chain A of 4M7E protein, causing potential exhibition of antioxidant and plant growth regulatory activities. Eventually, title compounds are identified as good blood-brain barrier (BBB)-penetrable compounds and are considered as proficient central nervous system active and neuroprotective antioxidant agents as the neuroprotective property is determined with BBB penetration thresholds.