Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule
Matthew J. Henley, Shelby K. Doyle, Angela N. Koehler
Topics & Concepts
Transcription factorCysteineCovalent bondDrug discoveryChemical biologyIntrinsically disordered proteinsChemistryCancer cellSmall moleculeCancer researchCancerBiologyBiochemistryGeneticsEnzymeGeneOrganic chemistryProtein Degradation and InhibitorsClick Chemistry and ApplicationsHistone Deacetylase Inhibitors Research