Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens
Abstract
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).
Topics & Concepts
SolubilityDissolutionChemistryActive ingredientCitric acidOxalic acidChemical stabilityChlorideIngredientOrganic chemistryPharmacologyMedicineFood scienceCrystallography and molecular interactionsCrystallization and Solubility StudiesCrystal structures of chemical compounds