ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation
Adriana Foster, Poppy Downing, E. Figredo, Nicole Polain, A. Stott, Robert Layfield, Sarah L. Rea
Topics & Concepts
TANK-binding kinase 1BiologyPhosphorylationAutophagyKinaseCell biologyIκB kinaseAmyotrophic lateral sclerosisFOXO3UbiquitinSignal transductionCancer researchNF-κBProtein kinase AGeneticsGeneProtein kinase BMAP kinase kinase kinaseMedicineInternal medicineDiseaseApoptosisAmyotrophic Lateral Sclerosis ResearchAutophagy in Disease and TherapyNeurogenetic and Muscular Disorders Research