The Role of Chemokines in Cervical Cancers
Fabian Garrido, Carl Mathis Wild, Johanna Mittelberger, Franziska Dobler, Mariella Schneider, Nadine Ansorge, Melitta B. Köpke, A. Strieder, Nina Ditsch, Udo Jeschke, Christian Dannecker
Abstract
Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.