Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones
Jing Liu, Xiaopeng Liu, Hong Wu, Wei Yi, Fu‐Dong Lu, Kai-Rui Guo, Ying Cheng, Wen‐Jing Xiao
Abstract
An unprecedented triple catalytic, general ring-opening cyanation reaction of cyclopropyl ketones for the construction of γ-cyanoketones is described. The key is to merge photoredox catalysis with Lewis acid catalysis and copper catalysis to enable the selective cleavage of the carbon-carbon bonds and the selective coupling of the generated radical and cyanide anion.
Topics & Concepts
CyanationRing (chemistry)CatalysisChemistryCombinatorial chemistryPhotochemistryOrganic chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCyclopropane Reaction Mechanisms