A corollary discharge circuit in human speech
Amirhossein Khalilian-Gourtani, Ran Wang, Xupeng Chen, Leyao Yu, Patricia Dugan, D. B. Friedman, Werner Doyle, Orrin Devinsky, Yao Wang, Adeen Flinker
Abstract
When we vocalize, our brain distinguishes self-generated sounds from external ones. A corollary discharge signal supports this function in animals; however, in humans, its exact origin and temporal dynamics remain unknown. We report electrocorticographic recordings in neurosurgical patients and a connectivity analysis framework based on Granger causality that reveals major neural communications. We find a reproducible source for corollary discharge across multiple speech production paradigms localized to the ventral speech motor cortex before speech articulation. The uncovered discharge predicts the degree of auditory cortex suppression during speech, its well-documented consequence. These results reveal the human corollary discharge source and timing with far-reaching implication for speech motor-control as well as auditory hallucinations in human psychosis.