The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G <sub>2</sub> Arrest in Cryptococcus
Sophie Altamirano, Zhongming Li, Man Shun Fu, Minna Ding, Sophie R. Fulton, J. Marina Yoder, Vy M. Tran, Kirsten Nielsen
Abstract
Dysregulation of the cell cycle underlies many human genetic diseases and cancers, yet numerous organisms, including microbes, also manipulate the cell cycle to generate both morphologic and genetic diversity as a natural mechanism to enhance their chances for survival. The eukaryotic pathogen Cryptococcus neoformans generates morphologically distinct polyploid titan cells critical for host adaptation and subsequent disease.
Topics & Concepts
Cryptococcus neoformansBiologyPolyploidCell biologyCell cycleCell cycle checkpointCyclin-dependent kinaseCellPloidyGeneticsGeneFungal Infections and StudiesParasitic Infections and DiagnosticsPhytoplasmas and Hemiptera pathogens